Kyzatrex Explained
The First Oral Testosterone That Actually Works
Medically reviewed by Dr. Ana Lisa Carr, MD
Kyzatrex (testosterone undecanoate) is an FDA-approved oral testosterone capsule that is shifting the testosterone treatment paradigm. For the first time, men with low testosterone have an effective oral option … no injections, no topical gels, no patches. Just two capsules, twice a day, with food.
Approved in July 2022, Kyzatrex represents a breakthrough in testosterone therapy. Clinical studies have shown it to be up to 96% effective at restoring testosterone levels to the normal range, with a favorable safety profile that avoids many of the side effects associated with injectable and topical routes.
How Kyzatrex Works
Kyzatrex uses a novel formulation containing phytosterol esters that enhance the solubility of testosterone undecanoate. Unlike older oral testosterone products that were hard on the liver, Kyzatrex is absorbed through the intestinal lymphatic pathway … completely bypassing first-pass liver metabolism.
This lymphatic absorption means the testosterone enters your bloodstream without being processed by the liver first, which is why Kyzatrex showed no clinically significant changes in liver function tests throughout clinical trials.
Available Strengths
- 100 mg capsules … 400 mg daily (two capsules, twice daily)
- 150 mg capsules … 600 mg daily (two capsules, twice daily)
- 200 mg capsules … 800 mg max daily (two capsules, twice daily)
All doses are taken twice daily with food. Your Viking provider will determine the right starting dose and adjust based on your lab results.
Clinical Results
In a 6-month open-label clinical study, Kyzatrex demonstrated:
- Up to 96% efficacy at achieving testosterone levels within the normal range
- Average testosterone level of 451.9 ng/dL (serum Cavg)
- Consistent performance regardless of dietary fat content
- Minimal mean increase in systolic blood pressure (1.7 mmHg at 4 months)
- No drug-related serious adverse events
Patient-Reported Improvements
In clinical studies, patients (n=214) reported improvements in multiple areas as testosterone levels normalized, including energy, mood, sexual function, and overall sense of vitality and well-being.
Favorable Blood Parameters
After 6 months of Kyzatrex therapy, clinical data showed:
- Cholesterol decreased by an average of 11.1 mg/dL
- Triglycerides decreased by an average of 18.6 mg/dL
- Fasting insulin decreased by an average of 5.2 μu/mL
- Hemoglobin levels plateaued after 90 days of treatment
- PSA increase was minimal (0.15 ng/mL average)
Why Choose Oral Over Injectable?
- No injections … no needles, no injection site reactions
- No transference risk … unlike topical gels, there is no risk of transferring testosterone to a partner or child through skin contact
- Consistent levels … the low peak-to-trough ratio means more stable testosterone throughout the day
- Liver-friendly … lymphatic absorption bypasses first-pass liver metabolism
- Convenient … just two pills with breakfast and two with dinner
Is Kyzatrex Right for You?
Kyzatrex is indicated for testosterone replacement therapy in adult males with conditions associated with a deficiency or absence of endogenous testosterone. If you have been diagnosed with low testosterone (typically below 300 ng/dL) and are looking for an alternative to injections or topical treatments, Kyzatrex may be the right fit.
Your Viking provider will evaluate your lab results, symptoms, and health history to determine whether Kyzatrex is appropriate for your individualized protocol.