Peptides for Weight Loss

Peptides for Weight Loss

Peptides for weight loss

What are Peptides?

Peptides are strings of amino acids, but shorter strings than steroid hormones such as Testosterone.  Peptides attach themselves to the outside of cells and work their magic from the exterior of the cell wall.  Peptides generally have one job to do, they are very focused,  and they do their exceptionally well.  Steroid hormones work penetrate cells and affect the cell from the insde, they are longer strings of amino acids, are more complicated, and can perform many jobs.

 

 

Why Use Peptides for Fat Loss?

Peptides are used for fat loss because they can target fat cells.  There are several different peptides for weight loss, some FDA approved, others are still in clinical trials and can only be obtained as research chemicals.

 

What are the best Peptides for Weight Loss?

We have a lot of information available here and on our sister site, LiveLikeAviking.com.  There are many different fat loss peptides available but we will concentrate on the most effective ones here.

 

MK 677 - This peptide causes your body to produce more HGH (Human Growth Hormone).  HGH is a hormone steroid produced naturally in the body.  If you increase the production of HGH you also increase the metabolic effects of HGH wifch include:

  • Increased breakdown of stored fat (triglyceride), and increased use of this fat to create energy;
  • Counteracting the actions of insulin. Insulin moves sugar from the blood into cells.
  • Water retention; and
  • Stimulation of protein production which is a large component of muscles.

HGH FRAG - RESEARCH CHEMICAL, not intened for human consumption. HGH FRAG is a  Peptide said to be 12.5 times more potent for fat loss than HGH itself.  Because it is a peptide and, as such, is focused on a single job, it is one of the best peptides for weight loss.

Here is a video that Sam Ridgeway made that does a fabulous job of describing both peptides and how they work:

Phentermine - not a peptide, it is a Schedule IV drug, may be very useful for your weight loss plan.  More Phentermine information 

Phentermine

Phentermine (Adipex-P, Lomaira) is an amphetamine-like prescription medication used to suppress appetite. It can help weight loss by decreasing your hunger or making you feel full longer. Phentermine is also available in combination with topiramate for weight loss (Qsymia).

Like other prescription weight-loss drugs, phentermine is intended to be used as part of an overall weight-loss plan. It is indicated for people who are obese, and who have failed to lose enough weight with diet and exercise alone — not for people who want to lose just a few pounds.

Adtipotide - A Peptide that is currently in human trials, available only as a research chemical for the time being.

This is a very interesting peptide - as stated above, the peptides attach themselves to cells and work from the outside of the cell - Adipodtide does just that, it destroys the blood supply to fat cells, causing the fat cells to wither die.  This is an extremely promising drug with few side effects known so far.  Please see the video that Sam made - he discusses the pro's and con's of each of these fat loss peptides.  We have also included some articles about the weight loss peptides and some links to research studies.

Adipodtide is a RESEARCH CHEMICAL - Viking Alternative Medicine cannot prescribe or advocate the use of any research chemical for human consumption.

Adipotide

Articles and Research Studies

Killing fat cells by vascular targeting

Vascular targeting of adipose tissue as an anti-obesity approach Development of obesity is characterized by hypertrophy and hyperplasia of adipocytes in white adipose tissue (WAT). This process relies on concomitant angiogenesis. Results from experimental inhibition or depletion of cells comprising the vasculature in animal models have contributed to the understanding of the mechanisms governing expansion of WAT. Disruption of neovascularization might be potentially useful for obesity prevention. In addition, approaches in which the mature WAT…

Read More

Reversal of Obesity with Peptide

Reversal of obesity by targeted ablation of adipose tissue   Obesity is an increasingly prevalent human condition in developed societies. Despite major progress in the understanding of the molecular mechanisms leading to obesity, no safe and effective treatment has yet been found. Here, we report an antiobesity therapy based on targeted induction of apoptosis in the vasculature of adipose tissue. We used in vivo phage display to isolate a peptide motif (sequence CKGGRAKDC) that homes…

Read More

AOD 9604 Peptide Weight Loss

AOD-9604 is now available at Viking! What is this new peptide and is it really even “New”? I’ll discuss the benefits, pitfalls, and availability. If weight control is an issue for you, this compound should be on your list of daily medications, The correct name for this peptide is AOD 9604 however many people transpose the numbers and refer to it as AOD 9064.

I want to start off by saying I was going to wait a couple of weeks before making this video, but I couldn’t.
I kept on getting all Giddy like a 5 year old on Christmas morning.
Couldn’t contain my excitement.
I have absolutely no willpower.
Because today I’m going to introduce to you… a recently released peptide called AOD-9604. The letters AOD are an acronym, which stands for Advanced Obesity Drug. And it’s being touted as yet another remarkable substance that’s going to revolutionize weight loss.
Now I’ve been using it for about 2 weeks now.
Because I always want to know a product before I recommend it. And I can actually feel it working. Especially if you can fast for a few hours in the morning before eating your first meal.
But is this really a breakthrough or is it just marketing hype for something we’ve been discussing on this channel for well over a year now?
Before we answer that, let’s discuss what AOD-9604 allegedly does.
Number One. The Stimulation of Lipolysis and Fat Oxidation.. In layman’s terms, it helps you not only lose weight, but it helps you from getting fat in the first place.
Number Two. It doesn’t affect blood sugar levels like HGH or a secretagogue.
Number Three. It helps in the prevention of Osteoarthritis.
Number Four. It compliments BPC 157 by strengthening your joints and increasing the effectiveness of cartilage repair.
Yes, if you want to repair cartilage… an issue I hear about all of the time, you might want to consider a combination of BPC 157 and AOD-9604.
So far so good, everything sounds awesome.
But here’s where things get familiar. AOD-9604 is comprised of a fragment of the Amino Acid string that makes up Human Growth Hormone… specifically fragment 176 through 191.
And for those that have been watching my videos over the past year or so…
And yes, this will be on the test.
What else is made up of that exact same sequence?
You in the front with the white shirt…
Very good… you’re absolutely correct… HGH Frag.
So what do you say we get in our Time Machine and go back to December of 2018 when I first discussed HGH Frag…
I mean AOD-9604…
It’s the same thing… just watch…
And all of that is just as true today as it was over a year and a half ago.
But you want to know why this is so exciting?
It’s because HGH Frag is now pharmaceutical grade.
See, the problem with HGH Frag wasn’t that it didn’t work. It was finding a Research Chemical Company that made it correctly, consistently, and at the proper dose and strength.
But now, since it’s been approved for human use, and because it’s being manufactured by a legitimate compounding pharmacy,
That changes everything.
Is it cheap?
No it’s not cheap.
But it’s not ridiculously expensive either. I’m not going to give a price in this video because pricing is always subject to change.
I do want to set the expectation level though… AOD-9604 is not a miracle compound. It’s not going to miraculously melt all of your fat away. It’s a tool. A tool to be used in conjunction with a sensible diet and consistent exercise program.
What I’m trying to say is if you think you can veg out on the couch,  shoot HGH Frag between each Pop Tart you throw down your Pie Hole, and still lose weight
You’re going to be extremely disappointed.
You’d think that would be common sense, but there’s a reason I mention it.
And it’s the same reason they need a warning label on a plastic bag, telling you not put it over your head.
Now back to the reason I was going to wait to put this video out.
AOD-9604 is only available in the form of a Troche today.
But the injectable version is scheduled to be released around September 14th… less than 2 weeks from today.
And we all know if you inject something it’s going to work just a little better than the sublingual version.
So there you go.
HGH Frag. Pharmaceutical Grade. From Viking.
And don’t forget to pick up some BPC 157 along with it if you have cartilage issues.
Oh, and one more thing.
You are Never Too Old to Live Like A Viking.
Read More

Adipotide – A peptide for Fat Loss

Adipotide

A new drug  undergoing human clinical trials for eliminating fat cells

RESEARCH CHEMICAL ONLY AT THIS STAGE.

  • Established: 2011
  • Founder: Dr. Wadih Arap and Renata Pasqualini
  • Accessibility: Not yet available
  • Diet Type: Diet and cancer pill
  • Gender: Male and female

Background:

Adipotide is a new drug that is showing some promise in the area of obesity research. This drug was initially created as a cancer treatment designed to starve cancer cells of a blood supply so they would stop growing. The effects of Adipotide have shown that the drug actually starves fat cells of blood forcing them to die and be reabsorbed into the body. Initial tests were done on rats and then moved on to monkeys. The results from testing on rats showed a 30 percent decrease in body weight. After four weeks of daily injections of Adipotide followed by four weeks of non-treatment, 10 obese female rhesus monkeys lost an average of 11 percent of their body weight and 39 percent of fat deposits. Most of the loss was experienced during the non-treatment period.

The news isn’t all great where this drug is concerned though. Some of the main negative side effects to this drug included dehydration and small kidney lesions, which left untreated could lead to kidney failure. Once the drug was discontinued, these problems disappeared. However, as the drug progresses to human clinical trials, these side effects will need to be dealt with. Adipotide is still a long way from being available for purchase, but the initial studies do make it sound promising.

PRO

  • Initial studies look promising
  • Drug has been proven to reduce body weight and fat deposits in rats and monkeys
  • Fat loss continues even after drug is discontinued
  • Completely starves fat cells of blood supply so they die

CON

  • Drug causes dehydration
  • Can produce kidney lesions
  • Still in the initial testing phases
  • Raises more questions than answers at this point

CONCLUSION

The initial studies on Adipotide sound very promising, but there are some definite concerns that need to be addressed before this drug is available for human consumption. The drug was found to be ineffective for monkeys who were already lean so it also raises the question of if this drug would stop working once a certain weight or body fat level is reached. It appears that Adipotide is going through the proper channels for testing. This could be a great breakthrough in obesity research, but we must all remember the importance of addressing potentially dangerous side effects.

Read More

Adipotid slimming pill destroys fat cells

Adoptide

Adipotide: Novel fat-away pill promises groundbreaking achievements

11/28/2011
How many times has the pharmaceutical industry claimed in recent years to have discovered a new miracle cure for obesity? Also this year, American researchers present a new fat way pill to help you lose weight without strict diets or exercise.
The so-called adipotides condition the results of Dr. med. According to Renata Pasqualini and colleagues from the University of Texas in Houston, a reduction in fat cells, which manifests itself in a significant loss of body weight. The pill affects the blood supply to living tissue, thus preventing the supply of oxygen and food supply to the fat cells, whereupon they can not regenerate or reproduce and die. For the first time, the researchers at the University of Texas have tested the use of the novel fat way pill on rhesus monkeys and thus achieved a weight loss of on average eleven percent.
Lose up to 15 pounds in four weeks?
Adipotids have been successfully tested on mice for years, and according to the US researchers, a weight loss of up to 40 percent was achieved in the animals. The researchers were also able to detect a similar effect in their experiments on rhesus monkeys. Together with her colleague Wadih Arap injected study lead dr. Renata Pasqualini obese rhesus monkeys adipotid and then observed their weight development. On average, the animals lost about eleven percent of body weight over the course of the four-week treatment, which would be equivalent to a weight-bearing adult weighing 10 to 15 kilograms, the US scientists said. Since rhesus monkeys and humans are very similar in their metabolic properties, Pasqualini and Arab were optimistic to be able to use the pill in humans with comparable success in the future. This would make adipotide as a pill in humans a novel alternative to losing weight. Since adipotide reduces fat cells altogether, the US researchers also say that the risk of subsequent weight gain is significantly lower than in previous preparations.
Slimming pill shows only minor side effects
The destruction of fat cells in adipotide makes the fundamental difference compared to the previous active ingredients. For example, earlier weight loss pills were more likely to relieve appetite or reduce the absorption of fats, for example by their absorption in the intestine. While Dr. Renata Pasqualini and dr. To explicitly warn Wadih Arap of the dangerous side effects of appetite suppressants, some of which have been banned by the European Medicines Agency and others are being reviewed for possible health problems, the US researchers point out the significantly reduced risk of side effects of adipotids. For example, the appetite suppressant sibutramine was banned in the EU as early as 2010, as it brings with it an increased risk of heart attack and stroke, and the EU is currently investigating possible liver damage caused by the fat intake blocker Orlistat. In adipotids, which attach directly to the fat cells, however, the side effects, in contrast to the previous weight loss methods are significantly lower, explained Pasqualini and Arap. In the laboratory experiments with animals, the adipotides have shown only very minor side effects, which, according to the US researchers, is due to the fact that the adipotides are targeted in their effect on specific blood vessels.
Clinical studies on the effects of adipotide planned
Now that the current research has been successful, the US researchers plan to conduct a 2012 clinical trial on patients with prostate cancer. These often suffer from a significant increase in the so-called depot fat and a corresponding increase in weight due to the cancer treatment with hormones. For years, Arap Pasqualini are looking for a drug that can stop the obesity of patients or even reverse – with the least possible side effects. This is the case with adipotide so the statement of the US researchers to the effect of the novel drug. Thus, the rhesus monkeys in the current study remained alert and attentive – with a constant appetite, explained the study director. Striking was the researchers, only the change in renal function values, but these had normalized relatively quickly after the end of the experiment. Regarding weight loss, the effect of Adopotide was quite long-term, so Pasqualini and Arap on. In a large part of the experimental animals, the weight loss continued even after the discontinuation of adipotide for several weeks, stressed the US researchers.
Criticism of weight loss pills
Although adipotide may be a relatively simple method of treating weight problems in overweight and obese individuals in the future, such preparations are well-controversial in the art. According to the critics, these should be used exclusively for overweight caused by illness or due to the treatment of illnesses. If the overweight is the result of an unhealthy lifestyle with lack of exercise and improper nutrition, such a weight loss pill would not only be the wrong signal but its effect probably only short-lived, so the criticism of the controversial preparations. In addition, there are the possible side effects that preclude the use of the weight loss pills in many cases when weighing the medical benefits.
Original article appeared in Health News
Read More

Adipotide Peptide for Weight loss in Clinical Trials

Peptides research

Adipotide Obesity Drug in Clinical Trials, Side Effects and Effectiveness Still in Question

News of a new weight loss drug called Adipotide surfaced early last year, but there haven’t been many updates since July regarding the status of the drug’s development. As reports suggest, Adipotide is still in trial phase being tested in clinical studies on humans. If approved, it would join Qsymia, Belviq and several others in the ‘miracle’ weight loss prescription drug line-up.

Adipotide was created by Dr. Wadih Arap and Renata Pasqualini as a form of cancer treatment as it was designed to starve cancer cells of blood supply prohibit them from growing. However, the effects of Adipotide have actually shown it starves fat cells of blood, which forces them to die and be reabsorbed into the body.

Though successful initial trials have been completed on rats and monkeys, some negative side effects have been noted, including dehydration and small kidney lesions that left untreated could lead to kidney failure.

Diets in Review resident pharmacist Dr. Sarah G Khan reports that Adipotide will be marketed as an injection into the subcutaneous layer of the skin, administered directly into the fat. While this may seem more effective, she believes this could be a potential downside as this method is not as user friendly.

“From looking at this drug over a year ago, I saw in their data that the initial results were great, but when the drug was discontinued blood flow resumed to those once blocked off fat cells and weight gain again started to occur,” said Khan. “I find it odd that they are using Adipotide in conjunction with treatment for another condition – prostate cancer.”

“From looking at this drug over a year ago, I saw in their data that the initial results were great, but when the drug was discontinued blood flow resumed to those once blocked off fat cells and weight gain again started to occur,” said Khan. “I find it odd that they are using Adipotide in conjunction with treatment for another condition – prostate cancer.”

As for whether she would recommend Adipotide as a safe weight loss method, she’s leaning toward no, erring on the side of more natural approaches.

“I honestly believe that if you are willing to go to your doctor’s office and get an injection then you would be willing to go to a nutritionist or a personal trainer,” she said. “I can’t even imagine what the cost of this medication will be but I expect, if approved, it will be expensive due to the way it’s administered. I have no doubt that people will be willing to pay a pretty penny for it. The drug mechanism seems similar to liposuction or Liposonix, which involve the fat being sucked out. However, proper nutrition still has to be practiced to prevent those fat cells from forming and growing again.”

Based on how poorly the weight loss drug Qsymia has been received thus far, some have wondered if there’s currently even a demand for drugs like Adipotide. Qysmia was released in summer 2020 and is still in what is called a REMS program, or Risk Evaluation and Mitigation Strategies, according to Dr. Khan. This is due to the potential risk for women of childbearing age to experience birth defects if they become pregnant. Though initial sales of Qsymia were lower than expected, the drug did see increases in late 2020. And Dr. Khan suspects this may be a result of the drug only being available through certified mail order pharmacies. The general public is not yet able to buy Qsymia at a retail pharmacy, but this could change as post-marketing studies become available, meaning sales could still go up.

Are Diet Drugs the Answer?

2020 has been a milestone year for the weight loss drug industry, with the FDA granting approval to both Loraserin (Belviq) and Qsymia – the first drugs to be approved since Alli in 1999. In light of these events and an ongoing discussion regarding the “ultimate weight loss solution,” we asked Dr. Khan what she believes Americans really need to keep in mind moving into the New Year.

“Americans need to get back to basics and start making time for themselves,” she said. “Being too busy and taking the easy way out leads to take-out, fast food and pre-made food, which is loaded with salt, fat and calories.”

Read More