Effects of Testosterone Supplementation on Separate Cognitive Domains in Cognitively Healthy Older Men: A Meta-analysis of Current Randomized Clinical Trials
W hilst well established risk factors for age-related cognitive decline include age, gender, and genetic risk, there is growing interest in the way that age-related decreases in hormone levels impact cognitive performance in older adults. Multiple reviews have reported on the relationship between endogenous testosterone (T) levels and cognition in older men.1−3 A growing number of clinical trials have also been published, examining the effects of testosterone supplementation (TS) on cognition in older men. However, there has yet to be a meta-analysis of the effects of TS on cognition. This paper addresses this pivotal gap in the literature by examining the effects of TS on individual cognitive domains in published, randomized clinical trials evaluating cognitively healthy older men, defined as individuals without Mild Cognitive Impairment (MCI) or dementia.