Adipotide: Novel fat-away pill promises groundbreaking achievements

11/28/2011
How many times has the pharmaceutical industry claimed in recent years to have discovered a new miracle cure for obesity? Also this year, American researchers present a new fat way pill to help you lose weight without strict diets or exercise.
The so-called adipotides condition the results of Dr. med. According to Renata Pasqualini and colleagues from the University of Texas in Houston, a reduction in fat cells, which manifests itself in a significant loss of body weight. The pill affects the blood supply to living tissue, thus preventing the supply of oxygen and food supply to the fat cells, whereupon they can not regenerate or reproduce and die. For the first time, the researchers at the University of Texas have tested the use of the novel fat way pill on rhesus monkeys and thus achieved a weight loss of on average eleven percent.
Lose up to 15 pounds in four weeks?
Adipotids have been successfully tested on mice for years, and according to the US researchers, a weight loss of up to 40 percent was achieved in the animals. The researchers were also able to detect a similar effect in their experiments on rhesus monkeys. Together with her colleague Wadih Arap injected study lead dr. Renata Pasqualini obese rhesus monkeys adipotid and then observed their weight development. On average, the animals lost about eleven percent of body weight over the course of the four-week treatment, which would be equivalent to a weight-bearing adult weighing 10 to 15 kilograms, the US scientists said. Since rhesus monkeys and humans are very similar in their metabolic properties, Pasqualini and Arab were optimistic to be able to use the pill in humans with comparable success in the future. This would make adipotide as a pill in humans a novel alternative to losing weight. Since adipotide reduces fat cells altogether, the US researchers also say that the risk of subsequent weight gain is significantly lower than in previous preparations.
Slimming pill shows only minor side effects
The destruction of fat cells in adipotide makes the fundamental difference compared to the previous active ingredients. For example, earlier weight loss pills were more likely to relieve appetite or reduce the absorption of fats, for example by their absorption in the intestine. While Dr. Renata Pasqualini and dr. To explicitly warn Wadih Arap of the dangerous side effects of appetite suppressants, some of which have been banned by the European Medicines Agency and others are being reviewed for possible health problems, the US researchers point out the significantly reduced risk of side effects of adipotids. For example, the appetite suppressant sibutramine was banned in the EU as early as 2010, as it brings with it an increased risk of heart attack and stroke, and the EU is currently investigating possible liver damage caused by the fat intake blocker Orlistat. In adipotids, which attach directly to the fat cells, however, the side effects, in contrast to the previous weight loss methods are significantly lower, explained Pasqualini and Arap. In the laboratory experiments with animals, the adipotides have shown only very minor side effects, which, according to the US researchers, is due to the fact that the adipotides are targeted in their effect on specific blood vessels.
Clinical studies on the effects of adipotide planned
Now that the current research has been successful, the US researchers plan to conduct a 2012 clinical trial on patients with prostate cancer. These often suffer from a significant increase in the so-called depot fat and a corresponding increase in weight due to the cancer treatment with hormones. For years, Arap Pasqualini are looking for a drug that can stop the obesity of patients or even reverse – with the least possible side effects. This is the case with adipotide so the statement of the US researchers to the effect of the novel drug. Thus, the rhesus monkeys in the current study remained alert and attentive – with a constant appetite, explained the study director. Striking was the researchers, only the change in renal function values, but these had normalized relatively quickly after the end of the experiment. Regarding weight loss, the effect of Adopotide was quite long-term, so Pasqualini and Arap on. In a large part of the experimental animals, the weight loss continued even after the discontinuation of adipotide for several weeks, stressed the US researchers.
Criticism of weight loss pills
Although adipotide may be a relatively simple method of treating weight problems in overweight and obese individuals in the future, such preparations are well-controversial in the art. According to the critics, these should be used exclusively for overweight caused by illness or due to the treatment of illnesses. If the overweight is the result of an unhealthy lifestyle with lack of exercise and improper nutrition, such a weight loss pill would not only be the wrong signal but its effect probably only short-lived, so the criticism of the controversial preparations. In addition, there are the possible side effects that preclude the use of the weight loss pills in many cases when weighing the medical benefits.
Original article appeared in Health News